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KMID : 0880220220600121178
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Journal of Microbiology
2022 Volume.60 No. 12 p.1178 ~ p.1190
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Characteristic alterations of gut microbiota in uncontrolled gout
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Asad ul-Haq
Lee Kyung-Ann
Seo Hoon-Hee
Kim Su-Kyung
Jo Su-Jin
Ko Kyung-Min
Moon Su-Jin
Kim Yun-Sung
Choi Jung-Ran
Song Ho-Yeon
Kim Hyun-Sook
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Abstract
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Microbiome research has been on the rise recently for a more in-depth understanding of gout. Meanwhile, there is a need to understand the gut microbiome related to uric acid-lowering drug resistance. In this study, 16S rRNA gene-based microbiota analysis was performed for a total of 65 stool samples from 17 healthy controls and 48 febuxostat-treated gout patients (including 28 controlled subjects with decreased uric acid levels and 20 uncontrolled subjects with non-reduced uric acid levels). Alpha diversity of bacterial community decreased in the healthy control, controlled, and uncontrolled groups. In the case of beta diversity, the bacterial community was significantly different among groups (healthy control, controlled, and uncontrolled groups). Taxonomic biomarker analysis revealed the increased population of g-Bifidobacterium in healthy controls and g-Prevotella in uncontrolled patients. PCR further confirmed this result at the species level. Additionally, functional metagenomics predictions led to the exploration of various functional biomarkers, including purine metabolism. The results of this study can serve as a basis for developing potential new strategies for diagnosing and treating gout from microbiome prospects.
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KEYWORD
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gout, gut microbiomes, uncontrolled gout, hyperuricemia, microbiota, Bifidobacterium, Prevotella, Bifidobacterium aldolescentis, Prevotella copri
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